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Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function

LAM, a typical virulence factor of Mycobacterium tuberculosis, can mediate the MAPK pathway and induce the expression of IL-10 and IL-12 through the differential activation of p38 MAPK and ERK1/2, thereby synergistically regulating the inflammatory microenvironment of host cells in conjunction with TLR2 (44, 72)