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Epigenetic mechanisms, such as DNA methylation, mediate the regulation of gene expression by environmental factors

From a kinetic perspective, many nanozymes deviate from conventional enzymatic models due to their multi-site, multifunctional, and multi-substrate characteristics, necessitating tailored kinetic frameworks to accurately describe their catalytic behavior

The siRNA encapsulation efficiency was greatly affected by the change of the DSPC to DOPE, whereas DOPE allowed a consistently high encapsulation efficiency with up to 70 % of ionizable lipid molar ratio, while the encapsulation efficiently greatly dropped under similar conditions while using DSPC (Leung et al., 2015)

doi:10.1590/S0004-2803.201900000-36 58 de Oliveira, C