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This study further supports that this local destabilization is dependent on the nature of a non-polar branched or medium-long aliphatic amino acid side chain

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In the present study, seed MDA and H 2 O 2 content were observed to be significantly elevated after 24 and 36 hours of exposure to 2.50 mg/mL of the fungal extract, with 84.47% and 85.52% increases in MDA and 137.17% and 141.10% increases in H 2 O 2 concentration, respectively

Niraparib showed promising activity in preclinical models and phase I clinical trials, achieving its pharmacodynamic target for PARP inhibition in epithelial ovarian cancer, particularly in patients who have responded to platinum-based chemotherapy 167 (Fig