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We highlight key E3 ubiquitin ligases and deubiquitinating enzymes (DUBs) that modulate the abundance of core clock components and their downstream effectors and discuss how disruptions in these processes can lead to circadian misalignment and disease

Additionally, patients with CD have lower levels of antioxidative substances such as plasma ascorbic acid, - and -carotene, lycopene, and -cryptoxanthin, as well as tissue GSH, which takes part in GPx-catalyzed H 2 O 2 reduction (161)

Early recognition and immediate withdrawal of offending agents is critical to minimize debilitating and potentially life-threatening consequences of severe drug rashes

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