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Besides, TQ prevented LPS-activated neuroinflammation in BV2 microglia by activating liver kinase B1 (LKB1), AMP-activated protein kinase (AMPK) and Sirtuin 1 (SIRT1) [50]

Although ABM domains were initially discovered (and named) for their roles in antibiotic biosynthesis 43 , they have since been shown to play more diverse roles in cellular metabolism with the discovery of their involvement in the enzymatic degradation of heme 52,53

They target distinct biological pathways, which is precisely why their combination (CagriSema) is under investigation offering broader metabolic coverage than either agent individually