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Additionally, HDAC6 inhibitors activate redox-regulating proteins like peroxiredoxins (reduce ROS) and support the function of the autophagy and ubiquitin-proteasome system (UPS) (both are impaired in PD patients) 62

Hence, the activation of the endogenous cannabinoid system using natural cannabis phytoproducts could potentially have favorable effects on regulating immunological responses, exhibiting antioxidant qualities, and alleviating symptoms associated with the autistic spectrum [113]

2003 Feb Marziyeh Ashoori, Ahmad Saedisomeolia

Human APOC3 transgenic mouse models were used to evaluate pharmacodynamic effects on reductions of serum APOC3, TG and LDL-C levels in vivo