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This was most recently shown by such studies as ASCEND (A Study of Cardiovascular Events in Diabetes) [71], STRENGTH (Long-Term Outcomes Study to Assess Statin Residual Risk with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridemia) [72], OMEMI (Omega-3 fatty acids in Elderly with Myocardial Infarction) [73] and VITAL (Vitamin D and Omega-3 Trial) trials [74]

Osteopontin: a bridge between bone and the immune system

doi: 10.1002/jmv.70287 72 ZhangDLiuZZhouYTangLHouJLiY

Notably, the efficacy of dietary restriction is tumor-specific: it only exerts potent effects on tumors highly dependent on the SSP, while showing limited efficacy in tumors with low SSP dependence or those capable of compensatory activation of the endogenous SSP (102)