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It is also noteworthy that metabolic dysfunction in CD8+ T cells, driven by the immunosuppressive microenvironment of chronic lymphocytic leukaemia (CLL), contributes to CAR-T therapy resistance (Van Bruggen et al, 2019)

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Even after adoption into nurturing families, these children retained enlarged amygdala volumes (68, 69), suggesting that early adversity can produce enduring changes in amygdala structure that may not be fully reversed by later positive environments