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Both nutrients work in close coordination within the methylation cycle, where vitamin B12 acts as an essential coenzyme for methionine synthase

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Therefore, there have been several attempts to use SAMe nutritional supplementation in clinical trials in AD [7]

In response to the CD3 monoclonal antibody, lymphocyte proliferation decreased approximately 66% in the placebo group over 6 months, compared with approximately a 3.7-fold enhancement in the anti-CD3 response in the ALA-treatment group