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Genetic predisposition also plays a role

Icariin alleviates IL-1-Induced Matrix Degradation by activating the Nrf2/ARE pathway in human chondrocytes

The detection of methylated circulating tumor DNA (ctDNA) of SEPT9 in blood is used as a screening method for colorectal cancer (CRC) (Laven-Law et al., 2024)

In nonalcoholic steatohepatitis, liraglutide can induce PINK1-Parkin-mediated mitophagy, which restricts the generation of ROS to suppress NLRP3-mediated hepatocyte pyroptosis [41]