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A planned trial of FMT in ALS will primarily look at tolerability and microbiome engraftment [223]

of the preamble of this FY 2024 IPPS/LTCH PPS proposed rule

Rather than addressing a single outcome, the focus is on supporting the broader hormonal and metabolic environment associated with growth hormone activity

The BDNF Val66Met variant affects activity-dependent plasticity and functional connectivity, influencing both pain modulation and responsiveness to stimulation (99, 100)