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2017, doi: 10.3748/wjg.v23.i48.8465

copri is enriched in human OA patients yet beneficial in mouse modelsurgently requires intensive investigation in multiple aspects, such as strain-specific differences (e.g., metabolic function distinctions between pathogenic and beneficial strains), dynamic regulation of the host immune microenvironment (e.g., the effect of inflammatory status on the microbiotahost interaction), and the effect of environment in influencing the effects of metabolites (for example, the effect of regulation of gut niches and availability of nutrient substrate for the production of bioactive entities such as paraxanthine)

If those compounds reach a cluster of subclinical precancerous cells, the result could be the pharmacological equivalent of pouring accelerant on a fire that was quietly burning at undetectable levels

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