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Bioavailability and bioequivalence Bioavailability Bioavailability is defined as: the fraction (percentage) of an administered dose of unchanged medicine that reaches the blood stream (systemic circulation)

Dysfunction in endothelial cells can result in heightened pulmonary vascular tone and vascular remodeling

B12 is also present in the muscles

Key Functions: Essential component of glutathione, the body's primary intracellular antioxidant Key element in sulfur-containing amino acids like cysteine and methionine Required for detoxification of xenobiotics and heavy metals Helps maintain protein structure through disulfide bonds Supports production of sulfation compounds that aid detoxification Unlike most minerals, sulfur doesn't have a specific RDA but is obtained through protein-rich foods including eggs, meat, fish, garlic, onions, and cruciferous vegetables