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First described by Hakaru Hashimoto in 1912, it continues to be a central entity in endocrine and autoimmune diseases due to its complex interplay of immune-mediated thyroid destruction and evolving thyroid dysfunction

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Most studies have concluded that excessive EPS matrix harms the wound environment and can lead to non-healing chronic wounds

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10.1111/j.1749-6632.1999.tb08645.x 42 Le PrellC

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