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7.1.1 Reprogramming macrophages: probiotics and phagocytic polarization As essential components of the innate immune system, macrophages defend the host by phagocytosing and destroying pathogenic microorganisms, including bacteria, viruses, and fungi (220)

Proof of this comes from observations that PKC inhibition with RBX enhances insulin action through phosphorylation of insulin- receptor substrate 1 (IRS1), Akt, eNOS, and GSK3 in STZ-DM and Zucker fatty insulin-resistant rats (73)

The relationship between food, mood, and behavior patterns runs deep, and disrupting it through pharmaceutical intervention can create psychological challenges that pure calorie counting never produces