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The immune response to SARS-CoV-2 in the respiratory tract has been shown to induce neuroinflammation, which subsequently leads to an acute inflammatory response and immune cell trafficking in the brain, and induces reactive states of resident microglia and other immune cells in the brain and brain borders [44, 51, 154]

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Enhanced fatty acid oxidation by selective activation of PPAR alleviates autoimmunity through metabolic transformation in T-cells

Although ADT is considered an effective therapy that confers survival advantage, undesirable side effects should be taken into consideration when designing the optimal treatment strategy