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It is also important in regulating blood glucose levels

DiebolderCABeurskensFJdeJong RNKoningRIStrumaneKLindorferMAet al

Molecular mechanisms regulating NPPCs in IDD Under conditions of elevated oxidative stress, excessive reactive oxygen species (ROS) accumulation and mitochondrial damage activate senescence pathways like P53/P21, contributing to accelerated ECM catabolism and NPPC senescence [76]