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This theory is further supported by the presence of Lewy bodies in the ENS even before their appearance in other areas of the body, including the CNS [117]

10.1101/gr.136101.111 96 WattsJ

The Q141K mutation is also linked with this phenotype of renal uric acid overload, both in patients who are homozygous for Q141K and those who are heterozygous for Q126X and Q141K