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Nonetheless, many clinical investigations are limited by short follow-up durations, small sample sizes, heterogeneous formulations, and reliance on surrogate endpoints, such as variations in bacterial diversity or inflammatory markers, rather than definitive clinical outcomes, thereby limiting the robustness of current conclusions (2, 4)

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The flow rate of mobile phase was 0.3 mL/min, which was constituted by solvents A (H 2 O+0.1% acetic acid) and B (Acetonitrile+0.1% acetic acid)

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