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Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo

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108,109 The clioquinol derivative PBT2 has been shown to inhibit Cu-induced A accumulation and possess greater BBB permeability and solubility

Studies have shown that hyperglycemia-induced mitochondrial fragmentation, mediated by an imbalance in fission and fusion proteins such as Drp1 and OPA1, contributes to mitochondrial dysfunction and impairs ATP synthesis in retinal capillary and Mller cells (16)