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In some embodiments, the level of pigmentation in localized areas is decreased towards a more uniform distribution of melanin or melanocytes by about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, by about 7%, about 7%, about 8%, about 9%, by about 10%, by about 12%, by about 15%, by about 17%, by about 20%, by about 25%, by about 30%, by about 35%, by about 40%, by about 45%, by about 45%, by about 50%, by about 55%, by about 60%, by about 65%, by about 70%, by about 75%, by about 80% or more

Genetic human Trx1-transgenic (Trx1-Tg) donor T cells or administration of human recombinant Trx1 to recipients of allogeneic hematopoietic transplantation (allo-HCT) could both considerably lessen the severity of graft-versus-host disease (GVHD) [45]

Regular assessments help tailor therapy to each patients needs.

Anti-sickling potential of cocoa and other biological activities are shown in (Figure 2 ) below