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A pivotal 2007 study published in the Journal of Physiology and Pharmacology examined rats with experimentally induced esophagitis and sphincter failure

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10.1093/ajcn/79.2.213 43 MagyarK.HalmosiR.PalfiA.FeherG.CzopfL.FulopA.et al (2012)

Remarkably, as seen in Fig 6D, the HP-INHIB-4488 inhibitor led to up-regulation of proinflammatory genes over the reference control, specifically at the basal (nonstarved) conditions and at 4 and 24 h of starvation, whereas the expression of ER stressassociated genes was up-regulated mostly at 24 h