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Concurrently, Drp1-mediated mitochondrial fragmentation significantly reduces synaptic ATP production, directly impairing synaptic transmission efficacy

Therefore, concentrations of MMA and total Hcy (tHcy) in plasma are priority markers for Cbl status

doi: 10.3390/toxins9040119 136 BrzozowaMMielanczykLMichalskiMMalinowskiLKowalczyk-ZiomekGHelewskiKet al

N-acetylcysteine also appears to have some clinical usefulness as a chelating agent in the treatment of acute heavy metal poisoning, both as an agent capable of protecting the liver and kidney from damage and as an intervention to enhance elimination of the metals