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Description

ATP released through GSDMD pores during pyroptosis acts as a secondary damage-associated molecular pattern, activating inflammatory signals in neighboring neutrophils and forming a self-reinforcing inflammatory amplification loop

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USA 100 , 685690 (2003)

The mechanism of action is still not completely clarified, but several studies reported pleiotropic effects in inhibition of the complex 1 of the mitochondrial respiratory chain (198, 199)