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coupled polyethylene glycol (PEG) with PAMAM or PEI, which could mitigate their toxicity, and then evaluated biodistribution in a healthy mouse model, which was measured to be highly active and safe[84]

Due to their enantioselectivity, they are also thought to act as selective filters, facilitating the production of NRPS products in a directed manner 14

The results strengthen our belief that CagriSema could be the first amylin-based combination therapy and a promising treatment option for individuals with type 2 diabetes, who also has a focus on weight loss. Following the results of REIMAGINE 1 and REDEFINE 3, Novo Nordisk will approach authorities to discuss the regulatory pathway for CagriSema in type 2 diabetes

A 2005 study by Finkley et al