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Some approaches include: BCL-2/BCL-xL inhibitors (e.g., navitoclax), tyrosine kinase inhibitors, metabolic stressors, or even immune-based clearance

The 21 healthy participants used either two placebo gums or two gums with 2.5 mg Pycnogenol each, six times daily for 15 min each

The explanation for this discrepancy can be found in recent papers showing that some cancer cell linesincluding HCT116are not affected by L-BSO or GSH synthesis inactivation because they can compensate GSH depletion by the thioredoxin (TXN) pathway 25 , and by maintaining protein homeostasis through deubiquitinating enzymes (DUB) 32