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Immunohistochemistry (IHC) Nucleus pulposus tissues were embedded in paraffin blocks and then cut into 7 m sections

It tends to be most prominent during perimenopause and usually resolves after menopause, and it is not normally a sign of permanent decline

Their work showed that oxidized LDL (oxLDL) activates oxidant stress and hypoxia signaling, transcriptionally upregulating NOS1 in CRC cells

While intermediate metabolites associated with TCA cycle (Tricarboxylic Acid Cycle) such as fumarate, succinate, and malate were not significantly different between the groups, we suggest a decrease in mitochondrial activity may result in lower ATP generation as reported in other inflammatory conditions (65, 66)