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Several lines of evidence point to upregulation of vascular endothelial growth factor receptor 2 (VEGFR2) signaling and modulation of the nitric oxide system [Huang et al., Vascular Pharmacology, 2015]

At night, stimuli are sent from the suprachiasmatic nuclei reaching the receptors of the superior cervical ganglion and the pineal gland, leading to the secretion of the hormone melatonin

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