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Numerous studies have indicated that in scenarios of iron overload, there is an increase in mitochondrial stress, which results in mitochondrial fragmentation and a disruption of the fission and fusion [68, 130]

Targeting GPX4 increases sensitivity to palbociclib in ER+ breast cancer cell lines The screen data suggested that CDK4/6 inhibition may create a GPX4-dependent state where cells rely on GPX4 to avoid ferroptosis

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J Ophthalmol 2011:14