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Authors contributions Study concept and design (TOA, BOE, CNE, CON), acquisition of data (TOA), drafting of the manuscript (TOA, CON), critical revision of the manuscript for important intellectual content (TOA, BOE, CNE, CON), administrative, technical, or material support (BOE, CNE), and study supervision (CON)

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Animal disease models are also flawed because of the inherent differences in the physiological nature of the BBB between animals and humans, so there is no way to tell if the results of experiments performed in animals are applicable to humans[193]