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In addition, in a rat renal ischemiareperfusion injury model, bardoxolone methyl decreased urea, creatinine, NGAL, total oxidant status, nitric oxide, and ADMA levels, increased SOD and GSH-Px activities, and upregulated renal Nrf2 and PPAR expression, suggesting that its anti-oxidative, anti-inflammatory, and anti-apoptotic effects collectively mitigate AKI severity (258)

doi: 10.3389/fimmu.2020.623691 10 ZhangWZouGLiBDuXSunZSunYet al

The development of biomarkers that can reflect the state of ferroptosis in the brain is crucial for enabling early diagnosis, assessing disease progression and monitoring therapeutic responses (Table II)

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