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306 Compared with mice reconstituted with p53(+/+) bone marrow, mice reconstituted with p53(-/-) bone marrow presented more severe atherosclerotic lesions and more lesion necrosis

Mutations in deoxyguanosine kinase ( DGUOK ), mitochondrial inner membrane protein MPV17 , polymerase catalytic subunit ( POLG ), succinate-CoA ligase GDP/ADP-forming subunit alpha ( SUCLG1 ), twinkle MtDNA helicase ( TWNK ) and transcription factors A ( TFAM ) have been associated with hepatocerebral MDDS, with acute liver failure in infancy and hypoglycemia

Zhai et al

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production