l-carnitine type 2 diabetes insulin sensitivity The Role of in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation Mechanisms linking obesity to insulin

The concept of a hypometabolic "dauer" state in ME/CFS is still being explored as a biological survival mechanism similar to hibernation, where organisms drastically downregulate their cellular functions in response to severe environmental stress

& Liggett, S

Interestingly, vitamin B12 deficiency itself can sometimes affect neurological function, potentially including the nerves that control bowel function, so treating a deficiency may actually improve rather than cause bowel symptoms in some cases

although, oral supplementation with L-citrulline, a precursor for arginine biosynthesis, has been shown to be more efficient than oral L-arginine in increasing plasma L-arginine [9], due to splanchnic catabolism of ingested L-Arginine [24]