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In a healthy organism, ROS, which include superoxide radical (O 2 ), singlet oxygen ( 1 O 2 ), H 2 O 2 , perhydroxyl radical O 2 H , or hydroxyl radical (OH ), regulate various physiological processes such as differentiation, stress signaling, long-distance signaling, redox levels, immune response, cell death, etc

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The accumulation of LDNs further suppresses immune responses and increases the risk of infection [84]