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Acta Pharmacol Sin (2022) 43(8):1889904

The most recent clinical trial candidate showing promise is ursodeoxycholic acid (UDCA), a drug often used in chronic inflammatory liver disease with an extensive safety profile (Sathe et al., 2020)

The Asp 2 analog, which had not been evaluated in the earlier studies, also exhibited pronounced inhibitory activity

The ferroptosis activator RSL-3 and the PI3K/Akt pathway inhibitor LY294002 reversed Neuritins inhibitory effect on ferroptosis, indicating that Neuritin suppresses neuronal ferroptosis via PI3K/Akt pathway activation (Song et al., 2025)