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In this phase, the liver attaches a glutathione molecule to a toxin (like a heavy metal or a byproduct of medication)

Among the predicted targets of miR-182 and miR-223, IGF-1R and FOXO3a were validated as their direct targets suggesting that HRT-mediated dysregulation of miR-182 and miR-223 induces the activation of IGF-1 signaling pathway by regulating IGF-1 signaling genes including IGF-1R and FOXO3a