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In cells with high expression of COX-2 (cancer cells), the nanoparticles disaggregate, inhibiting the enzyme activity and strongly increasing the fluorescence of the dye

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However, low to moderate levels of ROS can promote cancer cell survival and metastasis pathways through DNA damage-induced genomic instability, epigenetic regulation, metabolic reprogramming, and generation of pro-inflammatory and pro-tumorigenic microenvironment in a context-dependent manner [8, 12, 13, 26]