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In addition to inhibiting oncogenic signals, these compounds often activate stressresponse pathways in cells

Viability scores of 3 = motile, no changes to morphology and transparency, 2 = reduced motility and/or some damage to tegument as well as reduced transparency and increased granularity, 1 = severe reduction of motility and/or damage to tegument with high opacity and high granularity, and 0 = dead

Additionally, the safety data of Clostridium interventions in special populations such as children, pregnant women, and patients with severe immune deficiency are still lacking, and routine use is not recommended temporarily

Rev Endocr Metab Disord 25(1):215237