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Zofran is an antiemetic used to prevent nausea and vomiting

Plaza-Diaz J, Solis-Urra P, Aragon-Vela J, Rodriguez-Rodriguez F, Olivares-Arancibia J, Alvarez-Mercado AI

Variability in mucociliary clearance speed and mucus thickness, often affected by patient conditions such as anatomical differences, inflammation or allergies, and even the technique of administration (angle of spray, depth of insertion) (Riese et al., 2014), can alter drug absorption and uptake into the brain