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In this study, we systematically examined the physiological roles of Mtr in response to oxidative stress by overexpressing the mtr gene in C

Interestingly, FG4592 or hypoxia treatment alone increased ROS, as assessed by the cell-permeant 2,7-dichlorodihydrofluorescein diacetate (H 2 DCFDA), which is used as an indicator for ROS (Figure 5, C and D)

It has also been shown that BH4 deficiency, due to the lack of SPR activity, resulted in impaired mitophagy, a process required to maintain the quality and quantity of healthy mitochondria [124]

Blood sugar control (as assessed by the HbA1C test) is a primary goal of diabetes treatment (Delamater 2006