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10.1016/S0008-6363(98)00253-3 98

The R459 gating interaction with E220 appears to stabilise a bent conformation of TM11 (housing the critical carnitine-binding R471)

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Besides cardiovascular disease, TMAO also contributes to renal insufficiency and mortality risk in chronic kidney disease, type II diabetes, insulin resistance, non-alcoholic fatty liver disease and colorectal cancer as well (Tang et al., 2015