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doi: 10.1210/jcem.85.8.6720 74 BastardJPJardelCBruckertEBlondyPCapeauJLavilleMet al

Orthogonal cyclization strategies, including head-to-tail, side-chain to side-chain (e.g., disulfide bridges, lactam bonds, hydrocarbon staples), and backbone cyclization, enhance conformational rigidity and proteolytic resistance