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Crystallization The KRAS G13C protein was diluted to 2 mg/mL and incubated with a 3-fold excess of the acryl-bearing nucleotide 7b in 100 mM CHES (pH 9.5), 50 mM NaCl, 1 mM EDTA, 1 mM TCEP, and 5 % glycerol at room temperature

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine

METABOLIC SIGNALING PATHWAYS Effects of key metabolites Recent studies have highlighted the significant role of metabolites in influencing endothelial function and atherogenesis [Figure 1], with homocysteine metabolites being particularly impactful [107]

Studies have shown that that higher levels of leptin in plasma lead to obesity, hypertension, and other heart diseases [36]