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Risk Factors Shingles: Ageabout half of all patients are over 60 years Suppressed immune system Female sex Caucasian ethnicity HSV-1: Ageover 60% of Americans are infected by 50 years of age Receiving oral sex may increase risk of developing HSV-1 genital herpes HSV-2: Engaging in sexual activity with a partner who has an active, symptomatic infection Female sex (the prevalence of HSV-2 is almost 2 times higher in women than in men) Signs and Symptoms Shingles: First symptom is often burning or throbbing pain on one side of the body (unilateral) Pain may be accompanied by headache, malaise, earache, sensitivity to light, and/or fever After several days, a characteristic blistering rash may appear, which usually presents on one side of the body and is localized to a strip of skin Oral herpes: Painful sores in or around the mouth The affected area may be uncomfortable or painful before sores appear There may be a fever, swollen lymph nodes, and sore throat, which may make eating and drinking difficult Genital herpes: Sores on the penis, buttocks, anus, and around and inside the vagina, which may be painful The affected area may itch, tingle, or burn before the sores appear Fever, malaise, muscle aches, swollen lymph nodes in the groin, pain or burning upon urination, and vaginal discharge are common as well Diagnosis Both herpes and shingles are diagnosed mainly by physical examination

Nature 461 , 12431247 (2009)

(D) Schematic overview of an AuNP-coated MN-EAB patch designed for minimally invasive ISF microsampling and efficient signal transduction

Future research could focus on investigating the crosstalk among signaling pathways modulated by flavonoids, which would significantly enhance our understanding of their complex regulatory mechanisms