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Mechanistically, DMF regulates the expression of factors involved in the de novo cysteine synthesis (CBS), cystine uptake (SLC7A11), and GSH generation (GCLC, GCLM) through NRF2-dependent and independent pathways

A standard curve (e.g., using ascorbic acid or Trolox) can be used to quantify the antioxidant capacity of the sample

In addition to being administered as a drug to cause oxidative stress, MTX has also been used to induce cachexia, anorexia, intestinal mucositis and digestive absorption problem in experimental animal models (Reference Boukhettala, Leblond and Claeyssens34Reference Sinno, Coquerel and Boukhettala36)

Their main job is to turn nutrientsespecially fats, glucose, and amino acidsinto ATP, the molecule that fuels everything from brain signaling to muscle movement