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As a follow-up to the initial investigation, we analysed these proteins in samples from a separate and larger group of ND youth ( n =146

18,23,123 The prototypical example of a genetic primary astrocytopathy is Alexander disease, a leukomalacia in which astrocytes express mutant GFAP, although how the expression of this mutant gene translates into severe damage of the white matter remains unknown

Proper reconstitution with bacteriostatic water and passive dissolution (no shaking) preserves peptide structure and extends post-mixing shelf life

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