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doi: 10.1126/science.1092385 13 TalwarDMillerCGGrossmannJSzyrwielLSchweckeTDemichevVet al

This led to the development of a HER2 targeted monoclonal antibody, trastuzumab, which prevents ligand association with HER2 and ablates pathway activity, significantly improving patient survival (Slamon et al., 2001