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For example, liver assembles very low-density lipoprotein (VLDL) containing apolipoprotein B100 (apoB100) which delivers cholesterol to peripheral tissue and is eventually converted into LDL which is taken up by peripheral tissue via LDLR which may lead to several different outcomes including storage of cholesteryl esters 10,11,21,22,23,24,25,26,27,28,29