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Without knowing which marker is driving the breakouts, any treatment is a guess

Claudin-2-deficient mice are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules

If your doctor determines you have a deficiency, they may recommend you get vitamin B12 injections or take vitamin B12 supplements

Thus, future refinement of the model with non-linear reaction kinetics could improve the quantitative prediction capability of the model, specifically at higher overdose