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Perhaps we can better explain it visually, through an illustration taken from our article about cobalamin absorption (which we highly recommend to read): As you can see from the illustration, a problem in any part of the chain could lead to vitamin B12 malabsorption

The cytotoxic effects of three membrane-permeable NNMT inhibitors, 5-amino-1MQ, 7-amino-1MQ, and 2,3-diamino-1MQ were evaluated in 3T3-L1 pre-adipocytes